General
The increasing resistance to antibiotics requires new therapeutic approaches to combat bacterial infections. One promising alternative is the use of bacteriophages (phages), i.e. viruses that specifically infect and lyse bacteria. In recent decades, research has been carried out into how phages and antibiotics work either individually or in combination in animal models and clinical applications. Of particular interest is the phenomenon of phage-antibiotic synergy (PAS), in which antibiotics can stimulate phage production by bacterial hosts.
Studies show that certain antibiotics can increase the production of phages. This occurs because antibiotics cause cellular stress and thereby increase phage replication in the infected bacteria. This synergistic effect can improve the effectiveness of infection control and optimize bacterial elimination.
Biofilms are bacterial communities that are often resistant to antibiotics. Studies have shown that a combined therapy of phages and antibiotics can significantly improve the removal of biofilms. A sequential strategy in which phages were applied first, followed by antibiotic treatment, was particularly effective. This approach led to the greatest reduction in bacterial load in biofilm models.
In vivo studies predominantly show a synergy between phages and antibiotics. An enhanced antibacterial effect of the combination therapy was observed. In some cases, however, antagonism or indifference between phages and antibiotics was also observed. This illustrates that not every combination is equally effective and that the selection of suitable phage and antibiotic combinations plays a decisive role.
Recent clinical studies indicate that the simultaneous use of phages and antibiotics can lead to positive results in patients with severe bacterial infections. The combination of both therapeutic approaches could be particularly beneficial for patients with multidrug-resistant infections. However, further studies are required to determine the optimal dosage, duration of treatment and combinations.
The findings to date on phage-antibiotic interactions show promising possibilities for combating bacterial infections. While synergy has frequently been observed, cases of antagonism have also been documented. Targeted research and clinical evaluation of the best therapeutic approaches remains necessary to maximize the benefits of this combination therapy in medical practice.
Source: Bacteriophages and antibiotic interactions in clinical practice: what we have learned so far
The balance of your skin is our motivation
We are convinced that we can also do something good for your skin.
99.3% of our customers agree.
Our aim is to satisfy you with our products. If we still can’t convince you, you’ll get your money back*.
